An incorporated arithmetical model has been urbanized and investigated for CFD replication of a solitary cylinder, four stroke, straight inoculation, compressed ignition diesel engine of 3.5 kW for in-cylinder combustion analysis and authenticated under engine simulations at full load functioning conditions with foundation fuel diesel and 10% JME (volume basis) blend with diesel at invariable speed of 1500 rpm. For advancing the exactness of the exertion, a number of sub models, such as species transport model explaining the actual biodiesel energy content and molecular structure as soon as fuel blend is initiated, spray break-up model, wave model and pre-mixed combustion model are also initiated. Consequences of replication and the data from corresponding experimental investigation are evaluated to one another in terms of pressure traces, heat release rates. Excellent concurrences of pressure trace, heat release rate is accomplished involving the experimental and predicted data for all the tested fuels. The outcomes demonstrate that the anticipated mechanism offers reliable predictions of in-cylinder combustion.